Material has been edited for length and content.Fomepizole is an alcohol dehydrogenase inhibitor used in management of methanol and ethylene glycol poisoning.
This article is a rework of a press release issued by PLOS. Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease. Reference: Im H, Pearson ML, Martinez E, Cichos KH et al. “In conclusion, our study, to our knowledge, is the first report demonstrating that drug inhibitor targeting fermentation pathways has potential as an adjuvant to antibiotics,” the researchers write. This is important as people may present with other complicating factors such as other diseases or conditions, old age and environmental variables that may influence disease outcomes. Nevertheless, additional research in humans is required to determine if this novel drug treatment could be successful in treating patients. Combination treatment of erythromycin and fomepizole, an alcohol dehydrogenase inhibitor, prevented the in vivo dissemination of antibiotic-resistant Streptococcus pneumoniae.” Orihuela, the senior author of the study and professor of microbiology at the University of Alabama, summarized: “Pharmacological targeting of fermentation pathways is a new way to enhance the susceptibility of some bacteria to antimicrobials. They found that fomepizole – a drug that inhibits the enzyme alcohol dehydrogenase and is already FDA-approved to treat suspected methanol poisoning – was effective at blocking the bacteria’s energy production.įomepizole treatment also made the bacteria more sensitive to the antibiotic erythromycin when given in combination, reducing the burden of bacteria in the mice’s lungs and preventing the disease from becoming more invasive.Ĭarlos J.
The researchers conducted experiments using mice inoculated with a multidrug-resistant S. pneumoniae relies on the breakdown of sugar (glycolysis) and fermentation to generate energy, and the researchers in the current study set out to determine if disrupting this process could help to treat infections with S.
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